Copper Curiosity: From Blue Blood to Click Chemistry
نویسندگان
چکیده
منابع مشابه
Thiacycloalkynes for Copper-Free Click Chemistry**
Bioorthogonal chemistry enables the interrogation of biomolecules and physiological processes that are inaccessible by using conventional research tools. A common experimental protocol starts by labeling a target biomolecule in cells or live organisms with a bioorthogonal functional group. Then, a probe molecule bearing complementary functionality is added to the system and the ensuing bioortho...
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Chemical reactions that enable selective biomolecule labeling in living organisms offer a means to probe biological processes in vivo. Very few reactions possess the requisite bioorthogonality, and, among these, only the Staudinger ligation between azides and triarylphosphines has been employed for direct covalent modification of biomolecules with probes in the mouse, an important model organis...
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The ability to visualize biomolecules within living specimen by engineered fluorescence tags has become a major tool in modern biotechnology and cell biology. Encoding fusion proteins with comparatively large fluorescent proteins (FPs) as originally developed by the Chalfie and Tsien groups is currently the most widely applied technique. As synthetic dyes typically offer better photophysical pr...
متن کاملClick chemistry promoted by graphene supported copper nanomaterials.
A facile and robust approach is provided for the synthesis of highly dispersed copper nanoparticles immobilized onto graphene nanosheets, useful as a recyclable and reusable heterogeneous catalyst with excellent catalytic activity to achieve Cu(I)-catalyzed [3+2] cycloaddition 'click' chemistry.
متن کاملNew tetramethylthiepinium (TMTI) for copper-free click chemistry.
A new derivative of the strained 3,3,6,6-tetramethylthiacycloheptyne (TMTH) bearing a functional handle is reported. Following an optimized synthesis, the handle was introduced by mild alkylation of the sulphur atom. The resulting functionalized strained 4,5-didehydro-3,3,6,6-tetramethyl-2,3,6,7-tetrahydrothiepinium (TMTI) proved to be stable and underwent extremely fast [3+2] cycloaddition rea...
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ژورنال
عنوان ژورنال: Australian Journal of Chemistry
سال: 2019
ISSN: 0004-9425
DOI: 10.1071/ch19144